@article {202,
	title = {Highly permeable artificial water channels that self-assemble into two-dimensional arrays},
	journal = {Proceedings of the National Academy of Science},
	volume = {112},
	year = {2015},
	month = {07/2015},
	pages = {9810-9815},
	chapter = {9810},
	abstract = {<p>Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. We characterized a new architecture of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0({\textpm} 0.3){\texttimes}10<sup>-14</sup>\&nbsp;cm<sup>3</sup>/s or 3.5({\textpm} 1.0){\texttimes}10<sup>8</sup>\&nbsp;water molecules/s, which is in the range of AQPs (3.4~40.3{\texttimes}10<sup>8</sup>\&nbsp;water molecules/s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0{\texttimes}10<sup>8</sup>\&nbsp;water molecules/s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to ~10<sup>7</sup>\&nbsp;water molecules/s). Furthermore, within lipid bilayers, PAP channels can self-assemble into two-dimensional arrays. Importantly for permeable membrane design, the pore density of PAP channel arrays (~2.6{\texttimes}10<sup>5</sup>\&nbsp;pores/μm<sup>2</sup>) is two orders of magnitude higher than CNT membranes (0.1~2.5{\texttimes}10<sup>3</sup>\&nbsp;pores/μm<sup>2</sup>). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability and propensity to form arrays.</p>
},
	keywords = {membrane, nanochannel, permeation},
	doi = {10.1073/pnas.1508575112},
	author = {Yue-xiao Shen and Wen Si and Mustafa Erbakan and Karl Decker and Rita De Zorzi and Patrick O. Saboe and You Jung Kang and Sheereen Majd and Peter J. Butler and Thomas Walz and Aleksei Aksimentiev and Jun-li Hou and Manish Kumar}
}
