@article {302,
	title = {Step-defect guided delivery of DNA to a graphene nanopore},
	journal = {Nature Nanotechnology},
	year = {2019},
	month = {08/2019},
	abstract = {<p>Precision placement and transport of biomolecules are critical to many single-molecule manipulation and detection methods. One such method is nanopore sequencing, in which the delivery of biomolecules towards a nanopore controls the method{\textquoteright}s throughput. Using all-atom molecular dynamics, here we show that the precision transport of biomolecules can be realized by utilizing ubiquitous features of graphene surface-step defects that separate multilayer domains. Subject to an external force, we found that adsorbed DNA moved much faster down a step defect than up, and even faster along the defect edge, regardless of whether the motion was produced by a mechanical force or a solvent flow. We utilized this direction dependency to demonstrate a mechanical analogue of an electric diode and a system for delivering DNA molecules to a nanopore. The defect-guided delivery principle can be used for the separation, concentration and storage of scarce biomolecular species, on-demand chemical reactions and nanopore sensing.</p>
},
	isbn = {1748-3395},
	doi = {10.1038/s41565-019-0514-y},
	url = {https://doi.org/10.1038/s41565-019-0514-y},
	author = {Shankla, Manish and Aleksei Aksimentiev}
}
