@article {31,
	title = {Slowing down DNA translocation through a nanopore in lithium chloride.},
	journal = {Nano Lett},
	volume = {12},
	year = {2012},
	month = {2012 Feb 8},
	pages = {1038-44},
	abstract = {<p>The charge of a DNA molecule is a crucial parameter in many DNA detection and manipulation schemes such as gel electrophoresis and lab-on-a-chip applications. Here, we study the partial reduction of the DNA charge due to counterion binding by means of nanopore translocation experiments and all-atom molecular dynamics (MD) simulations. Surprisingly, we find that the translocation time of a DNA molecule through a solid-state nanopore strongly increases as the counterions decrease in size from K(+) to Na(+) to Li(+), both for double-stranded DNA (dsDNA) and single-stranded DNA (ssDNA). MD simulations elucidate the microscopic origin of this effect: Li(+) and Na(+) bind DNA stronger than K(+). These fundamental insights into the counterion binding to DNA also provide a practical method for achieving at least 10-fold enhanced resolution in nanopore applications.</p>},
	keywords = {DNA, Lithium Chloride, Models, Molecular, Molecular Dynamics Simulation, Nanopores, Nanotechnology, Particle Size, Surface Properties},
	issn = {1530-6992},
	doi = {10.1021/nl204273h},
	author = {Kowalczyk, Stefan W and David B Wells and Aleksei Aksimentiev and Dekker, Cees}
}
