@article {360,
	title = {Synthetic Macrocycle Nanopore for Potassium-Selective Transmembrane Transport},
	journal = {Journal of the American Chemical Society},
	volume = {143},
	year = {2021},
	month = {08/2021},
	pages = {15975-15983},
	chapter = {15975},
	abstract = {<p>Reproducing the structure and function of biological membrane channels, synthetic nanopores have been developed for applications in membrane filtration technologies and biomolecular sensing. Stable stand-alone synthetic nanopores have been created from a variety of materials, including peptides, nucleic acids, synthetic polymers, and solid-state membranes. In contrast to biological nanopores, however, furnishing such synthetic nanopores with an atomically defined shape, including deliberate placement of each and every chemical group, remains a major challenge. Here, we introduce a chemosynthetic macromolecule,\&nbsp;extended pillararene macrocycle (EPM) as a chemically defined transmembrane nanopore that exhibits selective transmembrane transport. Our ionic current measurements reveal stable insertion of individual EPM nanopores into a lipid bilayer membrane and remarkable cation type-selective transport, with up to a 21-fold selectivity for potassium over sodium ions. Taken together, direct chemical synthesis offers a path to de novo design of a new class of synthetic nanopores with custom transport functionality imprinted in their atomically defined chemical structure.\&nbsp;</p>
},
	keywords = {Electrical conductivity, MD Simulations, Nanopores, Potassium Ions Selectivity},
	doi = {10.1021/jacs.1c04910},
	author = {Qiao, Dan and Joshi, Himanshu and Zhu, Huangtianzhi and Wang, Fushi and Xu, Yang and Gao, Jia and Huang, Feihe and Aleksei Aksimentiev and Feng, Jiandong}
}
