@article {38,
	title = {Control and reversal of the electrophoretic force on DNA in a charged nanopore},
	journal = {J Phys Condens Matter},
	volume = {22},
	year = {2010},
	month = {2010 Nov 17},
	pages = {454123},
	abstract = {<p>Electric field driven transport of DNA through solid-state nanopores is the key process in nanopore-based DNA sequencing that promises dramatic reduction of genome sequencing costs. A major hurdle in the development of this sequencing method is that DNA transport through the nanopores occurs too quickly for the DNA sequence to be detected. By means of all-atom molecular dynamics simulations, we demonstrate that the velocity of DNA transport through a nanopore can be controlled by the charge state of the nanopore surface. In particular, we show that the charge density of the nanopore surface controls the magnitude and/or direction of the electro-osmotic flow through the nanopore and thereby can significantly reduce or even reverse the effective electrophoretic force on DNA. Our work suggests a physical mechanism to control DNA transport in a nanopore by chemical, electrical or electrochemical modification of the nanopore surface.</p>},
	keywords = {Base Sequence, Computer Simulation, DNA, Electromagnetic Fields, Electrophoresis, Models, Chemical, Molecular Sequence Data, Nanostructures, Porosity, Sequence Analysis, DNA, Static Electricity, Stress, Mechanical},
	issn = {1361-648X},
	doi = {10.1088/0953-8984/22/45/454123},
	author = {Luan, Binquan and Aleksei Aksimentiev}
}
