@article {386,
	title = {Super-Resolution Detection of DNA Nanostructures Using a Nanopore},
	journal = {Advanced Materials},
	year = {2023},
	month = {01/2023},
	pages = {2207434},
	abstract = {<p>Abstract High-resolution analysis of biomolecules has brought unprecedented insights into fundamental biological processes and dramatically advanced biosensing. Notwithstanding the ongoing resolution revolution in electron microscopy and optical imaging, only a few methods are presently available for high-resolution analysis of unlabelled single molecules in their native states. Here, we demonstrate label-free electrical sensing of structured single molecules with a spatial resolution down to single-digit nanometres. Using a narrow solid-state nanopore, we detect the passage of a series of nanostructures attached to a freely translocating DNA molecule, resolving individual nanostructures placed as close as 6\&nbsp;nm apart and with a surface-to-surface gap distance of only 2\&nbsp;nm. We attribute such super-resolution ability to the nanostructure-induced enhancement of the electric field at the tip of the nanopore. Our work demonstrates a general approach to improving the resolution of single-molecule nanopore sensing and presents a critical advance towards label-free, high-resolution DNA sequence mapping and digital information storage independent of molecular motors.</p>
},
	keywords = {biosensing, DNA nanostructures, Nanopores, single molecule, super resolution},
	doi = {https://doi.org/10.1002/adma.202207434},
	author = {Chen, Kaikai and Choudhary, Adnan and Sandler, Sarah E. and Maffeo, Christopher and Ducati, Caterina and Aksimentiev, Aleksei and Keyser, Ulrich F.}
}
