@article {392,
	title = {Sulfur-Containing Foldamer-Based Artificial Lithium Channels},
	journal = {Angewandte Chemie International Edition},
	volume = {62},
	year = {2023},
	pages = {e202305623},
	abstract = {<p>Abstract Unlike many other biologically relevant ions (Na<sup>+</sup>, K<sup>+</sup>, Ca<sup>2+</sup>, Cl<sup>-</sup>, etc) and protons, whose cellular concentrations are closely regulated by highly selective channel proteins, Li<sup>+</sup> ion is unusual in that its concentration is well tolerated over many orders of magnitude and that no lithium-specific channel proteins have so far been identified. While one naturally evolved primary pathway for Li<sup>+</sup> ions to traverse across the cell membrane is through sodium channels by competing with Na+ ions, highly sought-after artificial lithium-transporting channels remain a major challenge to develop. Here we show that sulfur-containing organic nanotubes derived from intramolecularly H-bonded helically folded aromatic foldamers of 3.6\&nbsp;{\r A}\&nbsp;in hollow cavity diameter could facilitate highly selective and efficient transmembrane transport of Li<sup>+</sup> ions, with high transport selectivity factors of 15.3 and 19.9 over Na<sup>+</sup> and K<sup>+</sup> ions, respectively.</p>
},
	keywords = {Foldamers, H-Bonds, Lithium Channels, Organic Nanotubes, Supramolecular Chemistry},
	doi = {https://doi.org/10.1002/anie.202305623},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202305623},
	author = {Shen, Jie and R, Deepa and Li, Zhongyan and Oh, Hyeonji and Behera, Harekrushna and Joshi, Himanshu and Kumar, Manish and Aksimentiev, Aleksei and Zeng, Huaqiang}
}
