Membrane Activity of a DNA-Based Ion Channel Depends on the Stability of Its Double-Stranded Structure
1 μs long equilibrium MD simulation of 4nm-2x structure. The complementary DNA strands are shown using turquoise and orange spheres, and the backbone of DNA is shown in tubular representation. The lipid bilayer is shown using turquoise lines and a representative carbon atom (C22) of the lipid headgroup is shown as turquoise and yellow spheres to distinguish the upper and lower leaflets, respectively. The cholesterol molecules are shown in green; water and ions are not shown for the sake of clarity.
1 μs long equilibrium MD simulation of 8nm-2x structure. The complementary DNA strands are shown using turquoise and orange spheres, and the backbone of DNA is shown in tubular representation. The lipid bilayer is shown using turquoise lines and a representative carbon atom (C22) of the lipid headgroup is shown as turquoise and yellow spheres to distinguish the upper and lower leaflets, respectively. The cholesterol molecules are shown in green; water and ions are not shown for the sake of clarity.
1 μs long equilibrium MD simulation of 8nm-0x structure, having a continuous DNA backbone. The complementary DNA strands are shown using turquoise and orange spheres, and the backbone of DNA is shown in tubular representation. The lipid bilayer is shown using turquoise lines and a representative carbon atom (C22) of the lipid headgroup is shown as turquoise and yellow spheres to distinguish the upper and lower leaflets, respectively. The cholesterol molecules are shown in green; water and ions are not shown for the sake of clarity.